Malkavians and Tremere are the more advanced of the traditional seven.
I sort of see the Brujah, Gangrel, Toreador, Nosferatu and Ventrue as 'entry level' clans. It's just that, in my experience, most newer players aren't up to the task. Now, all that said, I think characters from those clans can be played very well. 'I want to play a Banu Haqim ex-special forces assassin who uses two silver katanas and a silenced sniper rifle to hunt the werewolves who killed their entire family!' The other half want to play those clans, but as a basis for an even more ridiculous idea.
My issue is that players tend to play characters of those clans in a way where their clan basically IS their character concept. I know I’m in the minority, but I kinda hate Lasombra, Tzimisce, Baru Haqim, and Salubri.